e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Enantioselective catalysis of Ketoester-ene reaction of silyl enol ether to construct quaternary carbons by chiral dicationic palladium (ii) complexes
K Mikami, Y Kawakami, K Akiyama…
Index: Mikami, Koichi; Kawakami, Yuji; Akiyama, Katsuhiro; Aikawa, Kohsuke Journal of the American Chemical Society, 2007 , vol. 129, # 43 p. 12950 - 12951
Dicationic SEGPHOS-Pd complex-catalyzed ketoester-ene reaction with silyl enol ether can be achieved to produce an ene product with a quaternary carbon center in high yield and enantioselectivity. Even lower catalyst loading (up to 0.01 mol%) can be performed without a significant decrease in yield and enantioselectivity; this will open doors to industrial applications of chiral Lewis acid catalysis.
