Peptide nucleic acids containing adenine or guanine recognize thymine and cytosine in complementary DNA sequences

M Egholm, C Behrens, L Christensen…

Index: Egholm, Michael; Behrens, Carsten; Christensen, Leif; Berg, Rolf H.; Nielsen, Peter E.; Buchardt, Ole Journal of the Chemical Society, Chemical Communications, 1993 , # 9 p. 800 - 801

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Citation Number: 70

Abstract

Peptide nucleic acid (PNA) monomer building blocks for the introduction of G and A are prepared and used to synthesise H-TXT-Lys-NH (X= G or A), which are shown by measurements to recognize their complementary DNA sequences in both the parallel (N- terminal PNA/5′-DNA) and the anti-parallel mode; the stoichiometry