Experimental Study of Hydrogen Bonding Potentially Stabilizing the 5′??Deoxyadenosyl Radical from Coenzyme B12

…, W McFarlane, W Buckel, BT Golding

Index: Friedrich, Peter; Baisch, Ulrich; Harrington, Ross W.; Lyatuu, Fredrick; Zhou, Kai; Zelder, Felix; McFarlane, William; Buckel, Wolfgang; Golding, Bernard T. Chemistry - A European Journal, 2012 , vol. 18, # 50 p. 16114 - 16122

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Citation Number: 10

Abstract

Abstract Coenzyme B 12 can assist radical enzymes that accomplish the vicinal interchange of a hydrogen atom with a functional group. It has been proposed that the Co [BOND] C bond homolysis of coenzyme B 12 to cob (II) alamin and the 5′-deoxyadenosyl radical is aided by hydrogen bonding of the corrin C19 [BOND] H to the 3′-O of the ribose moiety of the incipient 5′-deoxyadenosyl radical, which is stabilized by 30 kJ mol− 1 (B. Durbeej et ...