Tetrahedron Letters

Enantioselective synthesis of β-hydroxyisobutyric acid: a useful synthon in the synthesis of polypropionate-type natural products

W Choy, P Ma, S Masamune

Index: Choy, William; Ma, Philip; Masamune, Satoru Tetrahedron Letters, 1981 , vol. 22, # 37 p. 3555 - 3556

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Citation Number: 18

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The aldol reaction of formaldehyde with the dicyclopentylborinyl enolate derived from -(or -) 1-tert-butyldimethylsilyloxy-l-cyclohexylbutan-2-one, followed by desilylation and sodium meta-periodate oxidation, provides -(or -) β-hydroxyisobutyric acid.