Synlett

Synthesis of Chiral Bifunctional (Thio) Urea N-Heterocyclic Carbenes

JP Brand, JIO Siles, J Waser

Index: Brand, Jonathan P.; Siles, Jose Ignacio Osuna; Waser, Jerome Synlett, 2010 , # 6 p. 881 - 884

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Citation Number: 11

Abstract

Abstract The rapid and modular synthesis of the first bifunctional N-heterocyclic carbenes bearing a (thio) urea moiety as H-bond donor group was reported. Different analogues could be accessed in seven steps from cheap (S)-pyroglutamic acid in good overall yields (14- 30%). The synthesized carbenes were active catalysts in the benzoin reaction.