Chemistry–An Asian Journal

Late??Stage Diversification of Chiral N??Heterocyclic??Carbene Precatalysts for Enantioselective Homoenolate Additions

P Zheng, CA Gondo, JW Bode

Index: Zheng, Pinguan; Gondo, Chenaimwoyo A.; Bode, Jeffrey W. Chemistry - An Asian Journal, 2011 , vol. 6, # 2 p. 614 - 620

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Citation Number: 22

Abstract

Abstract A library of chiral triazolium salts has been prepared by late-state diversification of a triazolium amine salt. By utilizing a primary amine as a functional handle, a single triazolium salt can be transformed into a variety of chiral N-heterocyclic carbene precatalysts. This approach makes the preparation of chiral N-heterocyclic carbenes possible by a single-step modification of a triazolium salt, rather than the usual need for multistep organic synthesis ...