e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Nucleosides and nucleotides. 100. 2'-C-Cyano-2'-deoxy-1-. beta.-D-arabinofuranosylcytosine (CNDAC): design of a potential mechanism-based DNA-strand-breaking …
A Matsuda, Y Nakajima, A Azuma…
Index: Matsuda; Nakajima; Azuma; Tanaka; Sasaki Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2917 - 2919
CNDAC). The inhibitory activity of CNDAC to human tumor cell lines in vitro and its antitumor activity on mouse leukemia P388 cells in vivo is also described. Introduction of the cyano group into the 2 '-“upn-position of 2 '-deoxycytidine would increase the acidity of the 2'- 'down”-proton. If this analogue were enzymatically incorporated into DNA molecules, the cyano group would be@ to the phosphate diester in the DNA molecule. Following the ...
![N-{2-Oxo-1-[(6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-1,2-dihydro-4-pyrimidinyl}acetamide Structure](https://image.chemsrc.com/caspic/091/140859-16-1.png)
