Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium …

…, F Ortega-Muro, W McDowell, P Castañeda…

Index: Horlacher, Oliver P.; Hartkoorn, Ruben C.; Cole, Stewart T.; Altmann, Karl-Heinz ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 264 - 268

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Citation Number: 43

Abstract

ACS Publications. ... Journal of Medicinal Chemistry. ... In vitro activated INH also forms adducts with NAD(P) cofactors that bind to and inhibit InhA and other enzymes like DHFR.(17) The physiological relevance of these interactions in vivo is clear in the case of InhA, while the ...