e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
α-Arylation of pyrrolidinones
JD Stewart, SC Fields, KS Kochhar…
Index: Stewart, Jon D.; Fields, Stephen C.; Kochhar, Kanwarpal S.; Pinnick, Harold W. Journal of Organic Chemistry, 1987 , vol. 52, # 10 p. 2110 - 2113
C (5)-C (4)-N (14)(115.0, 114.5'), C (4)-N (14)-C (16)(115.3, 115.2'), C (4)-C (5)-C (18)(119.6, 119.2'), and C (4)-C (3)-C (13)(120.7, 120.5 O). There are more short intramolecular distances and presumably more strain in 2 than in 1. In 2, these short distances are between the methyl group and hydrogen atom on the ring and the methyl groups on the nitrogen atom.