Journal of organometallic chemistry

An efficient and mild protocol for the α-arylation of ketones mediated by an (imidazol-2-ylidene) palladium (acetate) system

R Singh, SP Nolan

Index: Singh, Rohit; Nolan, Steven P. Journal of Organometallic Chemistry, 2005 , vol. 690, # 24-25 p. 5832 - 5840

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Citation Number: 32

Abstract

The activity of well-defined N-heterocyclic carbene (NHC)-palladium acetate complexes has been studied in the α-arylation of ketones. The enolate was generated in situ via use of slight excess of sodium tert-butoxide as base. The results showed a high activity, allowing for the coupling of non-activated chlorides. The use of hindered substrates provided an avenue for convenient synthesis of various ketone derivatives. The first examples of α- ...