Palladium complexes of 1, 3, 5, 7-tetramethyl-2, 4, 8-trioxa-6-phenyl-6-phosphaadamantane: Synthesis, crystal structure and use in the Suzuki and Sonogashira …

…, CS Frampton, AJ Robertson, J Hillhouse…

Index: Adjabeng, George; Brenstrum, Tim; Frampton, Christopher S.; Robertson, Al J.; Hillhouse, John; McNulty, James; Capretta, Alfredo Journal of Organic Chemistry, 2004 , vol. 69, # 15 p. 5082 - 5086

Full Text: HTML

Citation Number: 118

Abstract

Palladium complexes of 1, 3, 5, 7-tetramethyl-2, 4, 8-trioxa-6-phenyl-6-phosphaadamantane were prepared and characterized with Pd [1, 3, 5, 7-tetramethyl-2, 4, 8-trioxa-6-phenyl-6- phosphaadamantane] 2⊙ dba shown to be an effective catalyst for use in the Suzuki and Sonogashira reactions and the α-arylation of ketones. Couplings using this versatile complex proceeded in excellent yields under mild conditions.