Synthesis of anacardic acids, 6-[8 (Z), 11 (Z)-pentadecadienyl] salicylic acid and 6-[8 (Z), 11 (Z), 14-pentadecatrienyl] salicylic acid.

…, N Takeuchi, T Nishimura, T Ohta, S Tobinaga

Index: Satoh; Takeuchi; Nishimura; Ohta; Tobinaga Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 1 p. 18 - 22

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Citation Number: 10

Abstract

11-Chloro-3-methoxy-2-undecenal was synthesized from 8-bromooctanol, and an annelation reaction with this aldehyde and ethyl acetoacetate proceeded to give the ethyl 6- (8-chlorooctyl) salicylate. Ethyl 6-(8-chlorooctyl) salicylate was converted to ethyl 6-(7- formylheptyl)-2-methoxybenzoate through the iodide after protection of the phenolic hydroxyl group. Finally, the Wittig reaction with the aldehyde and triphenylphosphonium iodides in ...

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