Nucleophilic Substitution and Lipophilicity-Structure Relations in Methylazolopyridazines

A Katrusiak, M Ratajczak-Sitarz…

Index: Katrusiak, Anna; Ratajczak-Sitarz, Malgorzata; Skierska, Urszula; Zinczenko, Wiktoria Collection of Czechoslovak Chemical Communications, 2005 , vol. 70, # 9 p. 1372 - 1386

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Abstract

Abstract Syntheses of methyl [1, 2, 4] triazolo-or methyltetrazolopyridazine isomers, their separation and nucleophilic substitution with morpholine, dimethylamine and hydrazine have been described. The lipophilicity of the azolopyridazines has been measured and related to the number and sites of the methyl substituents. The structures of new methylated azolopyridazines have been characterized by 1 H NMR, MS spectra, and X-ray diffraction.