Benzimidazole condensed ring systems. 1. Syntheses and biological investigations of some substituted pyrido [1, 2??a] benzimidazoles

…, E El??Ghazzawi, O Kader, T Kappe

Index: Rida, Samia M.; Soliman, Farid S. G.; Badawey, El-Sayed A. M.; El-Ghazzawi, E.; Kader, O.; Kappe, Thomas Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1087 - 1093

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Citation Number: 24

Abstract

Abstract The synthesis of some substituted 3-hydroxy-1-oxo-1H, 5H-pyrido [1, 2-a] benzimidazole-4-carbonitriles and 4-ethyl carboxylates 3 and their 0-and N-dialkyl derivatives 5, 6 is described. 3-Ethoxy-5-ethyl-2-phenyl-1H, 5H-pyrido [1, 2-a] benzimidazol- 1-one 7 was obtained during the course of ethylating the parent ester 3t with triethyl phosphate. Chlorination of 3 with phosphorus oxychloride afforded the corresponding 1, 3 ...