Metal–arene complexes with indolo [3, 2-c]-quinolines: effects of ruthenium vs osmium and modifications of the lactam unit on intermolecular interactions, anticancer …

…, MA Jakupec, BK Keppler, W Berger, VB Arion

Index: Ginzinger, Werner; Muehlgassner, Gerhard; Arion, Vladimir B.; Jakupec, Michael A.; Roller, Alexander; Galanski, Markus; Reithofer, Michael; Berger, Walter; Keppler, Bernhard K. Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3398 - 3413

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Citation Number: 33

Abstract

Six novel ruthenium (II)–and osmium (II)–arene complexes with three modified indolo [3, 2-c] quinolines have been synthesized in situ starting from 2-aminoindoloquinolines and 2- pyridinecarboxaldehyde in the presence of [M (p-cymene) Cl2] 2 (M= Ru, Os) in ethanol. All complexes have been characterized by elemental analysis, spectroscopic techniques (1H, 13C NMR, IR, UV–vis), and ESI mass spectrometry, while four complexes were ...