Synthesis of 1, 4-Benzodiazepine-3, 5-diones

…, M Rogers-Evans, J Bergman

Index: Wiklund, Per; Rogers-Evans, Mark; Bergman, Jan Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6371 - 6376

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Citation Number: 20

Abstract

Even though benzodiazepines have a strong position in medicinal chemistry, very few synthetic routes to 1 H-1, 4-benzodiazepine-3, 5 (2 H, 4 H)-diones have ever been published and the claimed products have often been poorly characterized. Through the present work several 1 H-1, 4-benzodiazepine-3, 5 (2 H, 4 H)-diones have become available from N-carbamoylmethylanthranilic acids. The required ring closures were ...