One of the most 'atom-economical' means of preparing an amine is hydrogenation of an oxime where the only by-product is water. 7 The hydrogenation of indane-derived keto- or hydroxy-oximes has been known for almost four decades. 8 The cis-aminoindanols are formed in acidic media 9 whereas the trans isomers are formed predominantly in neutral or alkaline solution. Cis-aminochromanol 1 might also be accessible via reduction of the ...
