Letters in Organic Chemistry

A Versatile and Efficient Cu-Catalyzed N-Arylation of Aromatic Cyclic Secondary Amines with Aryl Halides

H Yang, Z Miao, R Chen

Index: Yang, Haitao; Miao, Zhiwei; Chen, Ruyu Letters in Organic Chemistry, 2011 , vol. 8, # 5 p. 325 - 331

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Abstract

Aryl-functionalized N-heterocyclic moieties play important roles in organic synthesis, pharmaceutical, or biological areas [1]. The most practical methods in synthesizing arylated N-heterocycle compounds are classic Ullmann-type coupling reactions [2]. Copper catalyzed Ullmann coupling is recognized as one of the most common synthetic protocols for their preparation [3]. However, these methods suffer from the harsh reaction conditions such as high ...