Tetrahedron letters

Regioselective synthesis of (±)-gabaculine hydrochloride

G Frater, U Müller, U Schöpfer

Index: Frater, G.; Mueller, U.; Schoepfer, U. Tetrahedron Letters, 1984 , vol. 25, # 3 p. 281 - 284

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Citation Number: 3

Abstract

Abstract 3-Cyclohexenecarboxylic acid (2) has been functionalized to the protected amino acid 5 in a novel reaction sequence, the crucial step being the acid catalysed cyclization of the γ, δ-unsaturated isocyanate 3 to the bicyclic lactam 4. 5 was converted into gabaculine hydrochloride (1· HCl).