Design, synthesis, and enzyme kinetics of novel benzimidazole and quinoxaline derivatives as methionine synthase inhibitors

H Elshihawy, MA Helal, M Said, MA Hammad

Index: Elshihawy, Hosam; Helal, Mohamed A.; Said, Mohamed; Hammad, Mohamed A. Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 550 - 558

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Citation Number: 4

Abstract

Abstract Methionine synthase catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine, producing methionine and tetrahydrofolate. Benzimidazole and deazatetrahydrofolates derivatives have been shown to inhibit methionine synthase by competing with the substrate 5-methyltetrahydrofolate. In this study, a novel series of substituted benzimidazoles and quinoxalines were designed and ...