Flavones. 3. Synthesis, biological activities, and conformational analysis of isoflavone derivatives and related compounds

…, D Gawlak, LA Radov, NP Gensmantel

Index: Wu; Loch III; Toder; Borrelli; Gawlak; Radov; Gensmantel Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3519 - 3525

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Citation Number: 57

Abstract

A aeries of 2-alkylisoflavone derivatives 1 was prepared with the intent to study the importance of the phenyl group (at the% position) of the isoflavone in impwting antihypertensive activity and the substitution effects at the 2-position of isoflavone. With the exception of the 2-isopropyl analog, the antihypertensive activity of these compounds appears to have a slow onset and long duration. None of the analogs appears better than ...