Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists

…, K Lu, M Packiarajan, V Jubian, G Chandrasena…

Index: Wu, Lingyun; Lu, Kai; Packiarajan, Mathivanan; Jubian, Vrej; Chandrasena, Gamini; Wolinsky, Toni C.; Walker, Mary W. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 6 p. 2167 - 2171

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Citation Number: 3

Abstract

A novel series of indolyl and dihydroindolyl glycinamides were identified as potent NPY5 antagonists with in vivo activity from screen hit 1. The dihydroindolyl glycinamide 10a significantly inhibits NPY5 agonist induced feeding at a dose of 0.1 mg/kg. The indolyl glycinamide 12c also inhibits NPY5 agonist induced feeding at a dose of 1mg/kg. Both compounds 10a and 12c represent potential tools for further investigation into the biology ...