Synthesis of a Chiral, Polydentate Ligand System Setting Out from L??Cysteine and First Nickel Complexes Thereof

DS Warner, C Limberg, S Mebs

Index: Warner, Dana Sabrina; Limberg, Christian; Mebs, Stefan Zeitschrift fur Anorganische und Allgemeine Chemie, 2013 , vol. 639, # 8-9 p. 1577 - 1583

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Citation Number: 4

Abstract

Abstract Setting out from protected L-cysteine a 2, 5-diketopiperazine V can be synthesized, the reduction of which with NaBH 4/TiCl 4 leads to (6R, 8aR)-7-methyl-6-(sulfanylmethyl)- thiazolidine [3, 4-a] piperazine, L 1 H as well as N, N′-dimethyl-(2R, 5R)-bis (sulfanylmethyl) piperazine, L 2 H 2, which were separated and characterized. L 2 H 2 can be obtained selectively, if V is reduced by NaBH 4/TiCl 4 in the presence of DIEA· HCl, ...