Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents

…, RL Adolphson, JA Kennedy, DO Thueson

Index: Connor; Cetenko; Mullican; Sorenson; Unangst; Weikert; Adolphson; Kennedy; Thueson; Wright; Conroy Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 958 - 965

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Citation Number: 75

Abstract

The synthesis and antiallergic activity of a series of novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles are described. A number of the compounds inhibit the release of histamine from anti-IgE stimulated basophils obtained from allergic donors. Optimal inhibition is exhibited in bermthiophenes with a 3-alkoxy substituent in combination with a 5-methoxy, 6-methoxy, or a 5, 6-dimethoxy group. Compound 13c (CI-959) also ...