Journal of fluorine chemistry

Kinetics and mechanism of the defluorination of 8-fluoropurine nucleosides in basic and acidic media

J Liu, JR Barrio, N Satyamurthy

Index: Liu, Jie; Barrio, Jorge R.; Satyamurthy, Nagichettiar Journal of Fluorine Chemistry, 2006 , vol. 127, # 9 p. 1175 - 1187

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Citation Number: 10

Abstract

For investigating the stability of C (8)–fluorine bond in 8-fluoropurine nucleosides some protected 8-fluoroguanosine, 8-fluoroinosine and 8-fluoroadenosine derivatives were prepared by direct fluorination of acetyl-protected purine nucleosides with elemental fluorine in solvents such as chloroform, acetonitrile and nitromethane. Fluorination reactions conducted in chloroform medium gave better yields of 8-fluoropurines. The fluorination ...