Synthesis of novel naphthoquinone aliphatic amides and esters and their anticancer evaluation

B Kongkathip, S Akkarasamiyo, K Hasitapan…

Index: Kongkathip, Boonsong; Akkarasamiyo, Sunisa; Hasitapan, Komkrit; Sittikul, Pichamon; Boonyalai, Nonlawat; Kongkathip, Ngampong European Journal of Medicinal Chemistry, 2013 , vol. 60, p. 271 - 284

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Citation Number: 10

Abstract

Fourteen new naphthoquinone aliphatic amides and seventeen naphthoquinone aliphatic esters were synthesized in nine to ten steps from 1-hydroxy-2-naphthoic acid with 9–25% overall yield for the amides, and 16–21% overall yield for the esters. The key step of the amide synthesis is a coupling reaction between amine and various aliphatic acids using 4- (4, 6-dimethoxy-1, 3, 5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) as a ...