Antihyperglycemic activity of novel naphthalenylmethyl-3H-1, 2, 3, 5-oxathiadiazole 2-oxides

JW Ellingboe, LJ Lombardo, TR Alessi…

Index: Ellingboe, John W.; Lombardo, Louis J.; Alessi, Thomas R.; Nguyen, Thomas T.; Guzzo, Frieda; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 17 p. 2485 - 2493

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Citation Number: 23

Abstract

A series of naphthalenyl 3H-1, 2, 3, 5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the dbldb mouse, a model for type 2 (non-insulin dependent) diabetes mellitus. Substitution at the 1-, 5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4-[(5-Chloronaphthalen-2- yl) methy1]-3H-1, 2, 3, 5-oxathiadiazole 2-oxide (45), one of the most potent compounds in ...

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