Pyrolysis of 1-substituted pyrazoles and chloroform at 550á░ C: formation of α-carboline from 1-benzylpyrazoles

IA Bhatti, RE Busby, M Mohamed

Index: Bhatti, Inayat A.; Busby, Reginald E.; Bin Mohamed, Murtedza; Parrick, John; Shaw, C. J. Granville Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 24 p. 3581 - 3585

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Citation Number: 4

Abstract

Pyrolysis of 13CH3 labelled 1-methylpyrazole 8 with chloroform at 550° C in a continuous flow reactor yields unlabelled 2-chloropyrimidine 9 and 2-cyanopyrrole 10 labelled at the cyano group. However, pyrolysis of 1-benzylpyrazole 14 with chloroform under similar conditions gives 9, 2-phenylpyrimidine 13 and, as the major product, α-carboline 15. Pyrolysis of several substituted 1-(arylmethyl) pyrazoles and the use of 13C and 15N ...

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