Tetrahedron

Chiral ligands containing heteroatoms: 13. Optically active 4-(2′-pyridyl)-1, 3-oxazolidines: An improved synthesis of 2-(2′-pyridyl)-2-aminoalcohols

S Conti, S Cossu, G Giacomelli, M Falorni

Index: Conti, Sandra; Cossu, Sergio; Giacomelli, Giampaolo; Falorni, Massimo Tetrahedron, 1994 , vol. 50, # 47 p. 13493 - 13500

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Citation Number: 14

Abstract

An improved synthesis of 2-(2′-pyridyl)-2-aminoalcohols 1a and 1b, in enantiomerically pure form via 1, 3-oxazolidine derivatives is presented. Some efficient and selective methods for both the cleavage of the oxazolidine ring and the removal of the N-Boc protecting group are also reported.