Organic letters

New P, N-Ferrocenyl Ligands for the Asymmetric Ir-Catalyzed Hydrogenation of Imines

MN Cheemala, P Knochel

Index: Cheemala, Murthy N.; Knochel, Paul Organic Letters, 2007 , vol. 9, # 16 p. 3089 - 3092

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Citation Number: 83

Abstract

The Ir-catalyzed enantioselective hydrogenation of various N-(3, 5-dimethyl-4-methoxy) phenylimines was performed under mild conditions in the presence of new P, N-ferrocenyl iridium complexes leading to (R)-N-(3, 5-dimethyl-4-methoxy) phenylamines in high yields and enantioselectivities (up to 99%). These chiral aryl amines can be readily deprotected using Ce (NH4) 2 (NO3) 6.