Synthesis and antineoplastic evaluations of 1, 4-bis (aminoalkanamido)-9, 10-anthracenediones

…, B Stefanska, M Bontemps-Gracz…

Index: Martelli; Dzieduszycka; Stefanska; Bontemps-Gracz; Borowski Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 1956 - 1959

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Citation Number: 23

Abstract

The effect of the replacement of amino groups, attached to the anthraquionone ring in [(aminoalkyl) amino]-anthraquinones, by an amido function on DNA binding, cytotoxicity, and antileukemic activity has been studied. The corresponding 1, 4-bis (aminoalkanamido)- 9, lO-anthracenediones have been synthesized and examined. It has been concluded that such modification does not exclude the DNA binding and cytotoxicity of mentioned ...