α, α-Difluoro-α-phenylsulfanyl-α-trimethylsilylmethane as a difluoromethyl building block: A general strategy to α, α-difluoromethyl aryl ketones

K Boonkitpattarakul, D Soorukram, P Tuchinda…

Index: Boonkitpattarakul, Kanhokthron; Soorukram, Darunee; Tuchinda, Patoomratana; Reutrakul, Vichai; Pohmakotr, Manat Journal of Fluorine Chemistry, 2011 , vol. 132, # 11 p. 987 - 990

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Citation Number: 12

Abstract

The synthetic utility of α, α-difluoro-α-phenylsulfanyl-α-trimethylsilylmethane (PhSCF2SiMe3; 1) as a difluoromethyl building block providing a general strategy to α, α-difluoromethyl aryl ketones was demonstrated. Oxidation, by using m-chloroperoxybenzoic acid, of the readily available 1-aryl-2, 2-difluoro-2-phenylsulfanyl-1-trimethylsiloxyethanes obtained from fluoride-catalyzed nucleophilic addition of PhSCF2SiMe3 with aromatic aldehydes ...