Fluorine-containing amino acids. IV. Synthesis and biological activity of β-polyfluoromethyl-substituted aromatic amino acids

MT Kolycheva, YL Yagupol'skii, LM Zaitsev…

Index: Kolycheva, M. T.; Yagupol'skii, Yu. L.; Zaitsev, L. M.; Gerus, I. J.; Kukhar', V. P.; Klebanov, B. M. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 2 p. 110 - 114 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 2 p. 159 - 163

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Abstract

Aromatic amino acids modified in the 8-position influence the metabolism of serotonin and catecholamines in the central nervous system (CNS), and possess psychotropic activity [5, 9, 12, 13]. In a search for new biologically active compounds in the fluorine, containing amino acid series, we synthesized earlier-unknown 8-(polyfluoromethyl) substituted derivatives of phenylalanine and tyrosine, and studied their influence on the CNS.