Practical Synthesis of PGI2 Agonist: Resolution–Inversion–Recycle Approach of Its Chiral Intermediate

A Ohigashi, A Kanda, S Moriki, Y Baba…

Index: Organic Process Research and Development, , vol. 17, # 4 p. 658 - 665

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Abstract

... Organic Process Research & Development. ... figure Scheme 3. Process chemistry route to (R)-7b based on the diastereomeric resolution approach with recycling of the ... a synthetic route to 7b via 16 based on several modifications to Hauser and Prasanna's route and procedure. ...