… Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2, 4-Trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2, 2, 2-trifluoroethyl)-2, 3-dihydro-1 H-benzo [e][1, 4] diazepin-3 …

…, JJ Baldwin, JW Butcher, DA Claremon…

Index: Selnick, Harold G.; Liverton, Nigel J.; Baldwin, John J.; Butcher, John W.; Claremon, David A.; Elliott, Jason M.; Freidinger, Roger M.; King, Stella A.; Libby, Brian E.; McIntyre, Charles J.; Pribush, David A.; Remy, David C.; Smith, Garry R.; Tebben, Andrew J.; Jurkiewicz, Nancy K.; Lynch, Joseph J.; Salata, Joseph J.; Sanguinetti, Michael C.; Siegl, Peter K.S.; Slaughter, Donald E.; Vyas, Kamlesh Journal of Medicinal Chemistry, 1997 , vol. 40, # 24 p. 3865 - 3868

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Citation Number: 105

Abstract

On the basis of its oral activity profile, 1 was chosen for detailed pharmacological study. The full hemodynamic profile of 1 in chloralose anesthetized dogs after iv administration showed dose dependent increases in QT intervals consistent with IKs blockade. There were no significant changes in ventricular excitation threshold, heart rate, or mean arterial pressure. There was also no effect on AV nodal or ventricular conduction. After dosing as a ...