e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Novel lopinavir analogues incorporating non-Aromatic P-1 side chains—Synthesis and structure–Activity relationships

HL Sham, C Zhao, L Li, DA Betebenner…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3101 - 3103

Full Text: HTML

Citation Number: 35

Abstract

... Bioorganic & Medicinal Chemistry Letters. Volume 12, Issue 21, 4 November 2002, Pages 3101–3103. Cover image Cover image. Novel lopinavir analogues incorporating non-Aromatic P-1 side chains—Synthesis and structure–Activity relationships. ...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

TERT-BUTYL ((2S,4S,5S)-5-(2-(2,6-DIMETHYLPHENOXY)ACETAMIDO)-4-HYDROXY-1,6-DIPHENYLHEXAN-2-YL)CARBAMATE Structure

TERT-BUTYL ((2S...

(2S,3S,5S)-5-Amino-2-(benzylamino)-1,6-diphenylhexan-3-ol Structure

(2S,3S,5S)-5-Am...

~%

TERT-BUTYL ((2S,4S,5S)-5-(2-(2,6-DIMETHYLPHENOXY)ACETAMIDO)-4-HYDROXY-1,6-DIPHENYLHEXAN-2-YL)CARBAMATE Structure

TERT-BUTYL ((2S...

(2S,3S,5S)-2-(N,N-DIBENZYLAMINO)-3-HYDROXY-5-(TERT-BUTYLOXYCARBONYLAMINO)-1,6-DIPHENYLHEXANE Structure

(2S,3S,5S)-2-(N...

~%

TERT-BUTYL ((2S,4S,5S)-5-(2-(2,6-DIMETHYLPHENOXY)ACETAMIDO)-4-HYDROXY-1,6-DIPHENYLHEXAN-2-YL)CARBAMATE Structure

TERT-BUTYL ((2S...

(2S,3S,5S)-2-(N,N-DIBENZYLAMINO)-3-HYDROXY-5-(TERT-BUTYLOXYCARBONYLAMINO)-1,6-DIPHENYLHEXANE Structure

(2S,3S,5S)-2-(N...

~%

[(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic acid 1,1-dimethylethyl ester Structure

[(1S,3S,4S)-4-A...

Di-tert-butyl dicarbonate Structure

Di-tert-butyl d...

~%

[(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic acid 1,1-dimethylethyl ester Structure

[(1S,3S,4S)-4-A...

(2S,3S,5S)-5-Amino-2-(benzylamino)-1,6-diphenylhexan-3-ol Structure

(2S,3S,5S)-5-Am...

~%

[(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic acid 1,1-dimethylethyl ester Structure

[(1S,3S,4S)-4-A...

[(1S,3S,4S)-4-Amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamic acid 1,1-dimethylethyl ester Structure

[(1S,3S,4S)-4-A...

~%

Lopinavir Structure

(2S,3S,5S)-5-Amino-2-(benzylamino)-1,6-diphenylhexan-3-ol Structure

(2S,3S,5S)-5-Am...

~%

Lopinavir Structure

(2S,3S,5S)-2-(N,N-DIBENZYLAMINO)-3-HYDROXY-5-(TERT-BUTYLOXYCARBONYLAMINO)-1,6-DIPHENYLHEXANE Structure

(2S,3S,5S)-2-(N...

~%

Lopinavir Structure

TERT-BUTYL ((2S,4S,5S)-5-(2-(2,6-DIMETHYLPHENOXY)ACETAMIDO)-4-HYDROXY-1,6-DIPHENYLHEXAN-2-YL)CARBAMATE Structure

TERT-BUTYL ((2S...

~%

Lopinavir Structure