N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors

…, E Axen, C Medina, J Uppenberg, S Svensson…

Index: Barf, Tjeerd; Lehmann, Fredrik; Hammer, Kristin; Haile, Saba; Axen, Eva; Medina, Carmen; Uppenberg, Jonas; Svensson, Stefan; Rondahl, Lena; Lundbaeck, Thomas Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1745 - 1748

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Citation Number: 43

Abstract

Small molecule inhibitors of adipocyte fatty-acid binding protein (A-FABP) have gained renewed interest following the recent publication of pharmacologically beneficial effects of such inhibitors. Despite the potential utility of selective A-FABP inhibitors within the fields of metabolic disease, inflammation and atherosclerosis, there are few examples of useful A- FABP inhibitors in the public domain. Herein, we describe the optimization of N-benzyl- ...