Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors

P Reigan, A Gbaj, IJ Stratford, RA Bryce…

Index: Reigan, Philip; Gbaj, Abdul; Stratford, Ian J.; Bryce, Richard A.; Freeman, Sally European Journal of Medicinal Chemistry, 2008 , vol. 43, # 6 p. 1248 - 1260

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Citation Number: 9

Abstract

Thymidine phosphorylase (TP) is over-expressed in various tumour types and plays an important role in tumour angiogenesis, growth, invasion and metastasis. The enzymatic activity of TP is required for the angiogenic effect of TP, therefore, inhibitors of TP are of significant interest in cancer chemotherapy. A series of xanthine oxidase (XO) activated prodrugs of known inhibitors of TP have been designed and synthesized with the ultimate ...