Synthetic communications

Organic Reactions in Ionic Liquids: Ionic Liquid Promoted Knoevenagel Condensation of Aromatic Aldehydes with (2??Thio) Barbituric Acid

Y Hu, ZC Chen, ZG Le, QG Zheng

Index: Hu, Yi; Chen, Zhen-Chu; Le, Zhang-Gao; Zheng, Qin-Guo Synthetic Communications, 2004 , vol. 34, # 24 p. 4521 - 4529

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Citation Number: 18

Abstract

The derivatives of the barbituric acid have been widely used as a sedative, hypnotic, anesthetic, anticonvulsant, antiosteoporosis, as well as an antitumor agent.1 View all references Arylidene (2??thio)barbituric acids are useful intermediates in synthesis of benzylbarbituric derivatives,[2]3. Frangin , Y. , Guimbal , C. , Wissocq , F. and Zamarlik , H. 1986. Synthesis of substituted barbituric acid via organozinc reagents. Synthesis, : 1046–1050.