Tetrahedron

Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction

…, K Takakura, H Abe, HS Kim, Y Wataya, T Harayama

Index: Takeuchi, Yasuo; Azuma, Kumiko; Takakura, Kentaro; Abe, Hitoshi; Kim, Hye-Sook; Wataya, Yusuke; Harayama, Takashi Tetrahedron, 2001 , vol. 57, # 7 p. 1213 - 1218

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Citation Number: 41

Abstract

Malaria is the world's most important tropical parasitic disease and there are an estimated 300–500 million cases of malaria each year. The emergence of multi-drug resistant strains of the parasite is exacerbating the situation. Febrifugine (d-1), which was isolated from Dichroa febrifuga and Hydrangea umbellata along with isofebrifugine (d-2), 1a–c is a well-known candidate antimalarial agent. The plane structure 2a of d-1 and d-2 was first proposed in 1950. ...