A systematic approach, which combines previously reported reactions with appropriate modifications, was established for preparing a variety of selectively deuterated nucleosides from glucose. We have developed a systematic method of synthesizing specifically deuterated nucleosides from glucose. Selectively 13C 2H-doubly labeled nucleosides, such as [1′, 2′, 3′, 4′, 5′-13C5; 3′, 5′-2H2]-and [1′, 2′, 3′, 4′, 5′-13C5; 4′, 5′ ...