Synthesis

Synthesis of novel 2-aryl AICAR derivatives

N Kohyama, T Katashima, Y Yamamoto

Index: Kohyama, Naoki; Katashima, Tomoyuki; Yamamoto, Yukio Synthesis, 2004 , # 17 p. 2799 - 2804

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Citation Number: 23

Abstract

Abstract Novel 2-aryl AICAR (5-Amino-1-β-d-ribofuranosylimidazole-4-carboxamide) derivatives 8 were synthesized via the Suzuki-Miyaura cross-coupling reactions of 8- bromoadenosine. Following conversion of the adenine moiety of 4 to hypoxanthine (5) and the introduction of a MEM group, hydrolysis of 7 gave desired 2-aryl AICAR derivatives 8.

~38%

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