Synthetic communications

Suzuki–Miyaura Cross??Coupling of Unprotected Halopurine Nucleosides in Water—Influence of Catalyst and Cosolvent

A Collier, GK Wagner

Index: Collier, Alice; Wagner, Gerd K. Synthetic Communications, 2006 , vol. 36, # 24 p. 3713 - 3721

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Citation Number: 23

Abstract

Abstract Reaction conditions for the Suzuki–Miyaura cross??coupling of unprotected halopurine nucleosides with arylboronic acids in aqueous media were investigated. A series of arylated purine nucleosides was prepared in water without an organic cosolvent, using either Pd (PPh3) 4 or Pd (OAc) 2/TPPTS as the catalyst.

~95%

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