Development of new mitomycin C and porfiromycin analogs

BS Iyengar, HJ Lin, L Cheng, WA Remers…

Index: Iyengar, Bhashyam S.; Lin, Horng-Jau; Cheng, Leung; Remers, William A.; Bradner, William T. Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 975 - 981

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Citation Number: 43

Abstract

New mitomycin C and porfiromycin analogues were prepared by treating mitomycin A and N- methylmitomycin A with a variety of amines, including aziridines, allylamines, propargylamines, chloroalkylamines, hydroxyalkylamines, glycine derivatives, aralkylamines, and heterocyclic amines. All analogues were evaluated against P-388 murine leukemia and selected ones were examined for their leukopenic properties. ...