A number of analogs of naturally occurring purine bases, which differ from the latter by replacement of a CH-group of the ring system by the isosteric N-atom have been shown to inhibit the growth of certain microorganisms. Among the compounds studied are derivatives of imidazo-1, 2, 3-triazine'and 5-amino-7-hydroxy-1-v-triazolo (d)-pyrimidine. 2, 3