Asymmetric Synthesis of Monofluorinated 1-Amino-1, 2-dihydronaphthalene and 1, 3-Amino Alcohol Derivatives

…, R Román, DM Sedgwick, G Haufe, P Barrio…

Index: Luebke, Martin; Jung, Manfred; Haufe, Guenter Journal of Fluorine Chemistry, 2013 , vol. 152, p. 144 - 156

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Citation Number: 6

Abstract

Enantioenriched 1-amino-4-fluoro-1, 2-dihydronaphthalene derivatives are accessed via two complementary synthetic strategies. The careful optimization of the reaction conditions required for the elimination step in one route has allowed both the identification of an