A lipase-catalyzed protocol for the synthesis of 5-hydroxyimino-4, 5-dihydrofurans via tandem coupling between β-nitrostyrenes and 1, 3-dicarbonyl compounds was developed in a 'one-pot'strategy. A series of β-nitrostyrenes were employed to expand the scope of this new biocatalytic promiscuity with high stereoselectivity (Z/E up to 99: 1) and moderate to good yields. The reaction activity of 1, 3-cyclohexanedione was found to be better than ...
[Nelson, John H.; Howells, Peter N.; DeLullo, George C.; Landen, George L.; Henry, Ronald A. Journal of Organic Chemistry, 1980 , vol. 45, # 7 p. 1246 - 1249]
