Nickel-catalyzed Michael additions of. beta.-dicarbonyls

…, PN Howells, GC DeLullo, GL Landen…

Index: Nelson, John H.; Howells, Peter N.; DeLullo, George C.; Landen, George L.; Henry, Ronald A. Journal of Organic Chemistry, 1980 , vol. 45, # 7 p. 1246 - 1249

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Citation Number: 133

Abstract

Bis (2, 4-pentanedionato) nickel (II) is found to be a mild, efficient, and simple to use catalyst for the Michael additions of P-dicarbonyls. Yields are higher than with traditional strongly basic catalysts, unwanted side reactions are reduced, and workup procedures are greatly simplified. The reactions appear to be quite general as (3-diketones, &keto esters,@-keto amides, and &diesters are all found to react. A rational mechanism which suggests further ...