Use of 5-deoxy-ribo-hexofuranose derivatives for the preparation of 5'-nucleotide phosphonates and homoribonucleosides

…, LI Kolobushkina, LN Beigelman

Index: Mikhailov, Sergei N.; Padyukova, Nelly Sh.; Karpeiskii, Marat Ya.; Kolobushkina, Lidiya I.; Beigelman, Leon N. Collection of Czechoslovak Chemical Communications, 1989 , vol. 54, # 4 p. 1055 - 1066

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Citation Number: 16

Abstract

Abstract A convenient and general method is proposed for the synthesis of 5'-nucleotide phosphonate analogs starting from 5-deoxy-1, 2-O-isopropylidene-α-D-xylo-hexofuranose which can easily be produced in preparative quantities from D-glucose. Phosphonate IIIe was synthesized by means of the Arbuzov reaction between 3-O-benzoyl-6-bromo-5, 6- dideoxy-1, 2-O-isopropylidene-α-D-ribo-hexofuranose and triethyl phosphite. The ...