Bioorganic & medicinal chemistry letters

5′-Homoaristeromycin. Synthesis and antiviral activity against orthopox viruses

M Yang, SW Schneller

Index: Yang, Minmin; Schneller, Stewart W. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 149 - 151

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Citation Number: 32

Abstract

An efficient synthesis of 5′-homoaristeromycin has been developed. This permitted an extensive antiviral analysis, which found potent activity toward vaccinia, cowpox, and monkeypox viruses. For comparative purposes, 5′-homoadenosine was made available by a newly designed route and found to be inactive.